ANADROXYL BY KALPA PHARMACEUTICALS

Tablets

DRUG COMPOSITION

1 tablet contains:
 - active substance: oxymetholonee 50 mg;
 - auxiliary substances: magnesium stearate, Kollidon® CL (crospovidone), FD&C Yellow No. 5, Ludipress® (lactose, povidone, crospovidone).

DRUG DESCRIPTION

Yellow tablets of square shape, flat top and bottom flat and bevelled edges on one side with a dividing line and printing "KP", and on the other side with the inscription "50", the side surface with rounded edges. A marbled surface of the tablets may be admitted.

PHARMACEUTICAL FORM

Tablets.

PHARMACEUTICAL GROUP AND ATC CODE

Androgen; anabolic steroid. A14A A05.

PHARMACOLOGICAL PROPERTIES

Pharmacodynamics
Anadroxyl is a strong anabolic steroid used mostly by the athletes in promoting muscle mass and increasing muscle strength. It also has some clinical indications, such as treatment of osteoporosis and anemia, but because of steroid-related side effects it is not a preferred drug for the enumerated causes. Therefore, oxymetholone is an efficient anabolic steroid with strong androgenic activities and very popular among athletes who seek muscle growth in a relative short period of time. It is a drug that has not proved to enhance performance ability of the athletes, and if used in the indicated dose range the risk of developing side effects is minimal.

Oxymetholone is an anabolic steroid. By penetrating into the cell nucleus, it stimulates the cell's genetic apparatus, which leads to increased synthesis of DNA, RNA and structural proteins, activates tissue-type enzymes and increases tissue respiration, oxidative phosphorylation, ATP synthesis and intracellular macrocellular accumulation.

It stimulates the anabolic processes and inhibits the catabolic ones caused by glucocorticoids. Increases muscle mass, reduces fat deposition, improves tissue trophic, favors calcium deposition in bones, retains sodium and water in the body.

Hematopoietic action is determined by the increase in erythropoietin synthesis. Androgenic (moderate) action may contribute to the development of male secondary sexual characteristics.

Pharmacokinetics
There is limited information on the pharmacokinetics of oxymetholone. It seems to be well absorbed with oral use. Oxymetholone has a very low affinity for sex hormone-associated globulin in human serum (SHBG), 5% less than testosterone and 1% less than DHT. This drug is metabolized in the liver by oxidizing at position C2, reducing at position C3, hydroxylation at position C17 and conjugation. The C2 hydroxymethylene group of oxymetholone may be dissociated to form mestanolone (17α-methyl-DHT), which may contribute to the effect of oxymetholone. The elimination half-life of oxymetholone is unknown. Oxymetholone and its metabolites are removed with urine.

PROFILE

Half life: 15-16 hours
Routes ofadministration: by mouth
Dosage forms: (Men): 50-150 mg / day; (Women): 12.5 mg / day
Acne: yes
Water retention: yes
High blood pressure: yes
Hepatotoxicity: yes (high, but studies were conducted on HIV-infected, they showed that taking 100 mg of oxymetholone per day for 30 weeks, no damage to the liver was observed, despite this there was an increase in ALT / AST, bilirubin, albumin and glutamyl transferase)
Aromatase: no (but it can itself affect the estrogen receptor)
Progestogen activity: no
DHT (dehydrotestosterone) conversion: no
Decreased HPTA function (own testosterone production): yes
Anabolic activity: 320%
Androgenic activity: 45%
Detection time: 1-2 months (approximately, due to the fact that DC is making progress in finding methods for detecting prohibited substances, it also depends on the athlete, whether he accepts phenobarbital and furosemide in order to speed up the withdrawal of the drug).

THERAPEUTICAL INDICATIONS

Disruptions of protein synthesis, cachexia of various genesis; trauma, burns, after infectious diseases and irradiation; muscular dystrophy, osteoporosis, negative nitrate balance in corticosteroid therapy, hypo- and aplastic anemia.

DOSES AND METHOD OF ADMINISTRATION

The recommended daily dose for adults and children is 1-5 mg / kg / day. The usual effective dose is 1-2 mg / kg / day, but higher doses may also be required, so doses need to be individualized. The answer does not happen immediately, so minimal treatment is 3-6 months. Patients with congenital aplastic anemia require continuous maintenance with maintained doses.

Recommended daily dosages range from 50 to 150 milligrams. It makes no sense to exceed them, since the effectiveness of the cycle will not increase. Professional women athletes can also use this drug. However, during the day they should not take more than 50 mg. Otherwise, virilization is possible. Most often the cycle with this drug lasts from six to eight weeks.

Anadroxyl comes in form of tablets that makes it easy to administer. Doses are set individually considering the weight, age, expected results and existing medical conditions. Generally, there is a dose range that is indicated for the first cycle of therapy. Each user should start with a lower dose and increase it until the most suitable dose is set. The duration of the therapy depends on how the drug works, and it may take a period of 3 months until all the desired results are obtained. It is recommended to take oxymetholone with food or milk in order to not experience stomach upset. Take the doses at the same time each day in order to better remember the schedule and not miss the doses. Benefit most of the drug by taking it as indicated and following certain doses. Do not increase the doses even if you consider that the drug does not show any results; better use it in combination with another steroid.

After canceling this anabolic, be sure to perform PCT using Nolvaxyl or Clomixyl. Only in this case, your cycle can be as safe as possible.

SIDE EFFECTS

In women:
- virilization symptoms, inhibition of ovarian function, menstrual disorders, hypercalcemia.

In men:
during the prepubertal period - symptoms of virilization, idiopathic skin pigmentation, retention or cessation of growth (calcification of epiphyseal growth zones of tubular bones);
post-puberty - bladder irritation, gynecomastia, priapism; in the elderly - hypertrophy and / or prostate carcinoma.

In men and women:
- progression of atherosclerosis, peripheral edema, dysregulation of liver function with jaundice, changes in leucocyte pattern, pain in long tubular bones, hypocoagula with tendency to haemorrhage.

Like in case of many anabolic steroids, Anadroxyl may cause side effects. In comparison with other mild steroids that do not cause estrogen related side effects, oxymetholone may cause such adverse reactions as acne, facial and body hair growth, changes in sexual desire and others. In order to avoid such side effects, it is recommended to take selective estrogen receptor modulators.

Some of the potential side effects associated with the use of oxymetholone are the following:

• Loss of appetite;
• Stomach pain;
• Breast swelling;
• Insomnia;
• Diarrhea;
• Feeling restless or excited.

CONTRAINDICATIONS

Hypersensitivity to the components of this drug, prostate cancer, breast cancer in men, mammary carcinoma in women with hypercalcemia, CPI, severe atherosclerosis, nephritis, nephrotic syndrome, liver and kidney failure, acute and chronic prostatitis, pregnancy, lactation period.

OVERDOSE

Cases of overdose have not been reported.

WARNINGS AND SPECIAL PRECAUTIONS FOR USE

When the first signs of virilization of the patients (voice thickening, hirsutism, acne, clitoromalgia) occur, administration should be stopped to avoid irreversible changes. Posology of coagulation factors II, VII, VII and X and prothrombin time may occur. Systemically control lipidemia and cholesterol. Pediatric use should be performed by an experienced specialist to avoid premature calcification of bone epiphyses.

INTERACTIONS WITH OTHER DRUGS

Glucocorticoids, mineralocorticoids, corticotropin, sodium-containing preparations and foods rich in sodium potentiate water retention in the body, increase the risk of developing edema, intensify acne eruptions. Increases the action of antiaggregants, anticoagulants, insulin and oral antidiabetics, decreases the action of somatotropin and its derivatives.

To unleash the full potential of Anadroxyl, it should be taken in combination with other anabolic steroids. It goes well with various drugs, but they must be injectable.

Such recommendations gives us its instruction. For example, an Anadroxyl - Sustaxyl 350 stack may be an excellent mass building. Take Anadroxyl daily in the amount of 50 milligrams. Sustaxyl must be injected once or twice within seven days, and the weekly dose of the drug is 350-700 milligrams. After reading Anadroxyl reviews, you will see that all of the above is true.

PRESENTATION, PACKAGING

50 mg tablets.
50 tablets in sachets.

STORAGE

Store in a dry place and away from light at 15-25 ° C. Keep out of the reach and sight of children.

LEGAL STATUS

It is issued with prescription.

DATE OF LAST TEXT CHECKS

July 2019

NAME AND ADDRESS OF THE MANUFACTURER

Kalpa Pharmaceuticals LTD
India
www.kalpapharmaceuticals.com